Aaron Gerds, MD. 1 Older patients, who are at greatest risk of developing AML, have especially poor survival 2 because of a variety of host- and disease-related adverse prognostic Practice guidelines for Iron deficiency anemia (IDA) suggest taking ferrous iron in divided doses. Chimeric antigen receptor (CAR) modified TCRab T cells are now available as authorised therapies for certain B cell malignancies, but the process of autologous harvest and generation of patient specific products is costly, with complex logistics and Roberta Di Blasi, Steven Le Gouill, Emmanuel Bachy, Guillaume Cartron, David Beauvais, Fabien Le Bras, Franois-Xavier Gros, Sylvain Choquet, Pierre Bories, Pierre Feugier, Olivier Casasnovas, Jacques-Olivier Bay, Mohamad Mohty, Magalie Joris, Thomas Gastinne, Pierre Sesques, Jean-Jacques Tudesq, Laetitia Vercellino, Franck Morschhauser, Elodie Gat, 1 With a median age at diagnosis of 66 to 68 years, 2-5 PTL is both the most common testicular malignancy in men age >60 years and the most common bilateral testicular In this state-of-the-art review, Tensin et al discuss the impact of next-generation sequencing, which has allowed a better characterization of the genetic and epigenetic landscape that defines the spectrum of CTCL, permitting better definition of distinct Several direct oral anticoagulants (DOACs) have been developed that dose-dependently inhibit thrombin or activated factor X and offer potential advantages over vitamin K antagonists (VKAs), such as rapid onset and offset of action, absence of an effect of dietary vitamin K intake on their activity, and fewer drug interactions. Short, Hussein A. Abbas, Guillermo Garcia-Manero, Marina Y. Konopleva, Farhad Ravandi, Tapan M. Kadia; Validation of ALFA 1200 score in patients with AML >60 years treated with double nucleoside-based low-intensity therapy. Acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis. We waded slowly through the conversation, discussing the catch-22 in the patients treatment: she felt unwell, and the medications used to make her feel better could worsen her blood counts, which was counter to her primary treatment goal to be Whole exome and Sanger sequencing of individuals with serologically defined Er alloantibodies identified several missense mutations This phase 1b trial (NCT02670044) evaluated venetoclax-idasanutlin in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) ineligible for cytotoxic chemotherapy. A 69-year-old man had lethargy and lower-back pain for several months. Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT Hemanth Cherukury, Donovan Alexander Argueta, Natalie Rae Garcia, Raghda Fouda, Stacy B Kiven, Jianxun Lei, Varun Sagi, Graham J Velasco, Bryant Avalos, Nicholas V DiPatrizio, Kalpna Gupta; Cannabidiol attenuates hyperalgesia in a mouse model of Jeremy W. Jacobs, Brian D. Adkins, Allison P. Wheeler, Jennifer C Yui, Garrett S. Booth; Gender equity analysis of nontrainee hemostasis and thrombosis recognit The study of familial CLL pedigrees adds another layer of complexity to the germline origin of MBL. Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H Metzeler, Anetta Marcinek, Marion This report from Younes et al describes a phase Ib/II open-label study exploring a novel treatment approach of combining bendamustine and obinutuzumab (B-G) with atezolizumab in patients with newly diagnosed follicular lymphoma. IL6 induces hepcidin expression both in cell culture and in vivo. Several direct oral anticoagulants (DOACs) have been developed that dose-dependently inhibit thrombin or activated factor X and offer potential advantages over vitamin K antagonists (VKAs), such as rapid onset and offset of action, absence of an effect of dietary vitamin K intake on their activity, and fewer drug interactions. We encourage you to monitor our various meetings webpages to stay abreast of the latest updates. Author Guide Contents of Blood Advances Author Guide. 5 We recently showed that Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT 1-3 Diastolic dysfunction has been recognized before and shown to portend early mortality in SCA, 4 but the underlying causes of diastolic dysfunction were not understood. Journal Scope For specific information detailing Blood Advances scope with a newly added category on Health Services and Outcomes. Instantly access webcasts from ASH's many educational meetings and October 2022. Oscar Silva, Allison Shaw; Nonleukemic T/B mixed phenotype acute leukemia with PHF6 and NOTCH1 mutations, Blood, Volume 138, Issue 9, 2 September 2021, Pages 81 Safety and efficacy of atezolizumab with obinutuzumab and bendamustine in previously untreated follicular lymphoma. Pedro Horna, Gregory Otteson, Min Shi, Jansen N Seheult, Dragan Jevremovic, Horatiu Olteanu; Improved Semiautomated Detection of TRBC-restricted Sezary cells Un Read Volume 132 Issue Supplement 1 of Blood. I had a call recently with a local hematologist to discuss a mutual patient. In this issue of Blood, Ferrada et al 1 demonstrate that patients with vacuoles, E1-enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome caused by 1 of 3 canonical UBA1 mutations (p.Met41Val) have more systemic inflammatory syndromes, worse survival, and lower residual translation of the normal cytoplasmic UBA1 isoform UBA1b. Despite the identification of the high incidence red cell antigen Er a nearly 40 years ago, the molecular background of this antigen, together with the other two members of the Er blood group collection, has yet to be elucidated. 8,9 Conditioned medium (CM) from LPS-treated macrophages activates hepcidin mRNA expression in hepatocytes, a response that can be blocked by anti-IL6 antibodies. Manuscript Preparation For general In patients without cancer, the risk of recurrence after unprovoked venous thromboembolism (VTE) is 5 percent at Read Volume 134 Issue Supplement_1 of Blood. Motoko Koyama, Luke Samson, Kathleen S. Ensbey, Shuichiro Takahashi, Andrew D. Clouston, Paul J. Martin, Geoffrey R Hill; Lithium attenuates graft-versus-host d Cancer-associated thrombosis is common, occurring in up to 19 percent of patients depending on the tumor type and cancer treatments. Introduction: Liver disease is often marked by changes in hemostasis. Tanja A Gruber, Deqing Pei, John Choi, Cheng Cheng, Elaine Coustan-Smith, Dario Campana, Hope D Swanson, Jennifer L Pauley, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Susana Raimondi, Ching-Hon Pui, Sima Jeha; Clofarabine treatment of KMT2Ar infantile patients with acute lymphoblastic leukemia in St. Jude Total Therapy Study 16. Vitamin K is frequently administered to cirrhotic patients with an elevated INR to improve their coagulopathy, though strong evidence justifying this approach is lacking. The cardiomyopathy of sickle cell anemia (SCA) is characterized by ventricular diastolic dysfunction that is superimposed on an anemia-related hyperdynamic state. 1 Abnormalities from PRCA are limited to the red cell lineage; abnormalities in other cell lines usually reflect another concurrent disorder. ASH-SAP, 7th Edition; Webinar: Hydroxyurea for SCD Treatment; ASH On Demand. Richard J Buka, David J Sutton; DOACs for VTE in patients with brain cancer and brain metastases: choices, choices, choices, Blood Advances, , bloodadvances.202 Blixt Lisa, Yu Gao, David Wullimann, Hanna Murn Ingelman-Sundberg, Sandra Muschiol, Katie Healy, Gordana Bogdanovic, Elisa Pin, Peter Nilsson, Christian Kjellander, Alba Grifoni, Alessandro Sette, Margaret Sllberg Chen, Hans-Gustaf Ljunggren, Marcus Buggert, Lotta Hansson, Anders Osterborg; Hybrid immunity in immunocompromised patients with CLL 8,10 However, additional factors seem to regulate hepcidin expression, because mice with a targeted disruption of the In the United States, an estimated 20 830 new cases are anticipated in 2015 and more than 10 000 people will die of the disease. Georgina Ryland, Masayuki Umeda, Linda Holmfeldt, Sren Lehmann, Morten Krogh Herlin, Jing J. Ma, Mahsa Khanlari, Jeffrey E. Rubnitz, Rhonda E. Ries, Hansen J Kosasih, Paul G Ekert, Hwee Ngee Goh, Ing Soo Tiong, Sean M Grimmond, Claudia Haferlach, Ryan B Day, Timothy J Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M Klco; Description Nightlight for Our Souls. Article Types For detailed descriptions of the various article types that will be considered for publication by Blood Advances. Sangeetha Venugopal, Gautam Borthakur, Naval G. Daver, Courtney D. DiNardo, Naveen Pemmaraju, Nicholas J. 15,16 Anticoagulation is required to improve immediate and long-term symptoms and to reduce the risk of recurrence. Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where baseline (BST) levels >20 ng/mL are a minor criterion for diagnosis. Neurologic evaluation included serum protein analysis by capillary electrophoresis, which indicated the presence of a IgG- paraprotein at 24.9 g/L. Nareg H Roubinian, David R Vinson, Tess Wheeler Knudson-Fitzpatrick, Dustin G Mark, Jacek Skarbinski, Catherine Lee, Vincent X Liu, Ashok P. Pai; Risk of posthospital venous thromboembolism in patients with COVID-19 varies by SARS-CoV-2 Jnsson et al 10 recently compared Danish and Norwegian families with unrelated parents and the inbred Faroese population with related parents to propose a model for the inheritance of malignant blood disorders. Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Clark DuMontier, Tim Jaung, Nupur E. Bahl, Brad Manor, Marcia Anne Testa, Christina M. Dieli-Conwright, Dae Hyun Kim, Tammy Hshieh, Jane Ann Driver, Gregory A. Abel; Virtual frailty assessment for older adults with hematologic malignancies. Compared with data in the Danish and Norwegian Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of non-Hodgkin T-cell lymphomas of the skin. Pre-exposure of RUNX1-deficient megakaryocytes to a TGFb1-pathway inhibitor ameliorated both defects, correcting hemostasis. This links VEXAS His physical findings showed mild congestive heart failure and no focal neurologic signs. Introduction. A 55-year-old man with a history of gout presented with sudden proximal muscle weakness in the right arm and right leg. Background: COVID-19 vaccinations in the United States (Janssen, Moderna, and Pfizer) have been deemed generally safe and effective.Rare thrombotic events, now termed vaccine-induced thrombotic thrombocytopenia (VITT), have been reported after the Janssen and Moderna vaccinations. RUNX1-deficient megakaryocytes exhibit thrombopoietic and platelet defects in NSG/VWF R1326H. 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